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Table 1 Clinical characteristics of different groups

From: Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis

Variables

Control

(n = 48)

IPF

(n = 211)

AE-IPF

(n = 57)

P-value

Mild

(n = 39)

Moderate

(n = 91)

Severe

(n = 138)

P-value

Demographic data

      

 Male, n (%)

29 (60.4)

182 (86.3)

49 (86.0)

 < 0.001

36 (92.3)

76 (83.5)

119 (86.2)

0.416

 Age, median, years

51.5 [39.8, 59.0]

66.0 [62.0, 73.0]

69.0 [64.0, 74.0]

 < 0.001

67.0 [55.0, 74.0]

66.0 [62.0, 72.0]

68.0 [63.0, 74.0]

0.219

 Smoker, n(%)

16 (33.3)

123 (58.3)

29 (50.9)

0.005

28 (71.8)

53 (58.2)

71 (51.4)

0.064

Pulmonary function

        

 FVC%, median

 

67.0 [56.7, 76.5]

50.8 [44.4, 63.2]

 < 0.001

76.9 [64.9, 89.7]

67.7 [58.8, 75.3]

58.8 [47.6, 70.4]

 < 0.001

 DLCO%, median

 

48.2 [37.4, 67.0]

31.1 [22.8, 42.8]

 < 0.001

71.4 [61.4, 81.6]

50.3 [42.0, 63.5]

34.4 [25.3, 44.1]

 < 0.001

 OI, median, mmHg

 

344.0 [395.0, 400.0]

175.0 [141.5, 232.5]

 < 0.001

364.0 [338.0, 422.5]

357.0 [316.0, 426.8]

251.5 [161.8, 328.0]

 < 0.001

Laboratory test

        

 WBC, median, 109/l

 

7.2 [6.0, 8.7]

8.8 [7.3, 11.3]

 < 0.001

6.6 [5.4, 7.9]

7.0 [5.7, 8.6]

8.1 [6.7, 10.0]

 < 0.001

 CRP, median, mg/l

 

5.4 [3.5, 15.4]

17.5 [6.4, 46.7]

0.002

4.4 [3.3, 6.9]

5.1 [3.5, 9.5]

9.9 [4.5, 36.1]

 < 0.001

 LDH, median, U/l

 

231.0 [203.0, 282.0]

348.0 [256.5, 435.5]

 < 0.001

212.0 [183.3, 243.0]

223.0 [202.0, 274.0]

278.0 [234.0, 370.3]

 < 0.001

 CC16, median, ng/ml

27.8 [21.8, 37.1]

79.7 [55.8, 117.2]

122.8 [85.2, 154.0]

 < 0.001

43.6 [33.1, 61.1]

79.9 [61.1, 123.7]

100.8 [74.1, 140.3]

 < 0.001

 KL-6, median, ng/ml

198.5 [165.3, 298.0]

969.2 [575.0, 1370.5]

1945.0 [1184.5, 2601.5]

 < 0.001

610.5 [503.3, 954.3]

938.2 [588.8, 1210.8]

1387.0 [863.0, 2285.0]

 < 0.001

Outcome

        

 1 year mortality

0 (0)

38 (18.0)

42 (73.7)

 < 0.001

0 (0)

5 (5.5)

75 (54.3)

 < 0.001

 2 years mortality

0 (0)

77 (36.5)

51 (89.5)

 < 0.001

1 (2.6)

16 (17.6)

111 (80.4)

 < 0.001

 3 years mortality

0 (0)

96 (45.5)

53 (93.0)

 < 0.001

2 (5.1)

29 (31.9)

118 (85.5)

 < 0.001

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European Journal of Medical Research

ISSN: 2047-783X

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