Impact of ventilatory and laboratory parameter trajectories on short-term survival in acute respiratory distress syndrome patients: a retrospective study using joint models

Table 4 Joint models

Parameter	Association (current-value)	Lower 95 CI	Upper 95 CI	HR	p
Respiratory rate [/min]	0.06866	0.02639	0.1109	1.07	0.0015
Minute ventilation [L]	− 0.09818	− 0.1520	− 0.04436	0.91	0.0004
Tidal volume [ml/kg of ideal bodyweight]	− 0.3264	− 0.4417	− 0.2111	0.72	< 0.0001
Driving pressure [mbar]	0.1513	0.09472	0.2078	1.16	< 0.0001
Log₂ of Horovitz index [mmHg]	− 2.1077	− 2.6162	− 1.5992	0.12	< 0.0001
Log₂ of Procalcitonin [ng/ml]	0.3325	0.2293	0.4358	1.39	< 0.0001
PEEP [mbar]	0.2811	0.1913	0.3709	1.32	< 0.0001
P_peak [mbar]	0.1837	0.1294	0.2380	1.20	< 0.0001
CRP (sqrt) [mg/l]	0.1312	0.07443	0.1880	1.14	< 0.0001
Leucocytes (sqrt) [GPt/L]	− 0.02325	− 0.1928	0.1462	0.98	0.7873

Parameter	Association (slope dependent)	Lower 95 CI	Upper 95 CI	HR	p
Respiratory rate [/min]	0.5877	− 0.00857	1.1840	1.80	0.0534
Minute ventilation [L]	− 1.0156	− 1.6527	− 0.3784	0.36	0.0019
Tidal volume [ml/kg of ideal bodyweight]	− 2.7083	− 4.0486	− 1.3681	0.07	< 0.0001
Driving pressure [mbar]	1.9606	1.2518	2.6695	7.10	< 0.0001
Log₂ of Horovitz index [mmHg]	− 8.3579	− 12.4653	− 4.2505	0.0002	< 0.0001
Log₂ of Procalcitonin [ng/ml]	2.4995	1.6955	3.3034	12.18	< 0.0001
PEEP [mbar]	2.6039	1.8329	3.3750	13.52	< 0.0001
P_peak [mbar]	1.1877	0.7618	1.6137	3.28	< 0.0001
CRP (sqrt) [mg/l]	1.4467	0.8911	2.0023	4.25	< 0.0001
Leucocytes (sqrt) [GPt/L]	0.001461	− 2.6301	2.6331	1.00	0.9991

Data are association coefficient, 95% confidence interval (CI), Hazard ratio (HR), significance (p). CRP C-reactive protein; GPt gigaparticles; L litre; Log₂ logarithm to base 2; PEEP positive end-expiratory pressure; P_peak peak airway pressure; sqrt square root

ISSN: 2047-783X