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Fig. 6 | European Journal of Medical Research

Fig. 6

From: NF-κB-mediated enhancement of H3K27me3 through EZH2: a mechanism to suppress pyocyanin-induced autophagy in macrophages

Fig. 6

NF-κB inhibits autophagy in THP-1 macrophages. A Western blot analysis of cytoplasmic and nuclear NF-κB expression levels in THP-1 macrophages treated with PYO and/or Curcumin (10 μM for 12 h), using β-actin and H3 as respective cytoplasmic and nuclear markers. B Western blot analysis of LC3B II expression in THP-1 macrophages treated with PYO and/or Curcumin. Densitometric analysis showing cytoplasmic and nuclear NF-κB (C), and LC3B II/LC3B I levels (D), normalized to the DMSO group. ChIP–qPCR analysis of the enrichment of NF-κB at the promoter regions of E ULK1 and F MAP1LC3B genes. Data are presented as mean ± SD, n.s. not significant, *P < 0.05, **P < 0.01, n = 3

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European Journal of Medical Research

ISSN: 2047-783X

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