Fig. 2

Functional analyses of the differentially expressed genes in the tumor core region (TCR) vs. cancer-adjacent tissue (CAT) groups. a Heatmap of the differentially expressed genes between TCR and CAT; b Volcano plot showing the upregulated (red) and downregulated (blue) genes; c Gene Ontology (GO) functional analysis; d Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis