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Fig. 4 | European Journal of Medical Research

Fig. 4

From: Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways

Fig. 4

Quercetin ameliorates ox-LDL-induced cell cycle arrest and apoptosis of aortic endothelial cells possibly through down-regulating p16 and p21. A Representative flow cytometry for cell cycle of ox-LDL-induced HAECs with treatment of quercetin (Que) or transfection of p16 (si-p16) or p21 (si-p21) siRNA or negative control (si-NC). B, C Quantification of G0/G1 phase and S phase percentages in the above HAECs. D Representative flow cytometry for apoptosis of ox-LDL-induced HAECs treated with Que or transfected with si-p16, si-p21 or si-NC. E Quantification of apoptotic HAECs. F Representative white light photographs of ox-LDL-induced HAECs with Que administration or si-p16, si-p21 or si-NC transfection. Scale bar, 100 μm. G CCK-8 for cell viability of the above HAECs. **p < 0.01; ****p < 0.0001

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European Journal of Medical Research

ISSN: 2047-783X

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