Fig. 7

Analysis of the correlation between MCM8 expression and angiogenesis-related genes in ESCA. a Correlation plot illustrating the significant positive association between MCM8 expression and a panel of 36 angiogenesis-related genes in ESCA samples, as determined by the GEPIA online tool (p < 0.05). b Heat map and associated statistical analysis from TCGA ESCA dataset showing a consistent positive correlation between MCM8 and the expression of 15 angiogenesis-related genes (p < 0.05). Heat plot highlighting the predominant significant positive correlation between MCM8 and PTK2 expression in the GSE45670 dataset (p < 0.05). c, d Scatter plots show angiogenesis-related genes (PTK2) significantly positively correlated with MCM8 expression levels in TCGA and GSE45670 datasets and confirm that the expression of PTK2 is also significantly different between the high and low MCM8 expression groups