Fig. 6

Correlation analysis of MCM8 expression with m6a methylation genes in ESCA. a Correlation plot from the GEPIA online tool demonstrating a significant positive correlation between MCM8 expression and a panel of 20 m6a-associated genes in ESCA (p < 0.05). b Heat map illustrating the consistent positive correlation between MCM8 and the 20 m6a genes in TCGA ESCA dataset (p < 0.05). c Heat plot highlighting the significant positive correlation of MCM8 expression with HNRNPA2B1, RBMX, and YTHDF1 in the GSE45670 dataset (p < 0.05). d Scatter plots displaying the significant positive correlation between MCM8 and the m6a genes HNRNPA2B1, RBMX, and YTHDF1 in TCGA and GSE45670 datasets. e Bar chart showing the significant differential expression of 18 m6a genes in TCGA ESCA dataset between high and low MCM8 expression groups. f Bar chart indicating significant expression differences for two m6a genes, HNRNPA2B1 and YTHDF1, between high and low MCM8 expression groups in the GSE45670 dataset. g Venn diagram illustrating the positive association of HNRNPA2B1 and YTHDF1 with MCM8 expression levels in the analyzed datasets