Fig. 4

Immunohistochemical analysis of MCM8 expression in ESCA. a Representative images of tissue microarray (TMA) sections showing MCM8 protein expression, which was predominantly localized to the cytoplasm. b MCM8 was significantly overexpressed in ESCA tissues compared with adjacent normal tissues (p < 0.05). c, d No significant association was observed between MCM8 expression and patient age or gender (p > 0.05)