Fig. 6

Role of CFLAR in immune infiltration and immunotherapy. A Correlation between CFLAR expression and the abundance of 24 types of tumor-infiltrating immune cells. Absolute values of Spearman correlation coefficient (R) were measured based on the size of the dots. B Heatmap through TIMER2.0 to pan-cancer evaluate the association between CFLAR expression and immune cell infiltration. C Scatter plots demonstrating the correlation between CFLAR expression and T cell infiltration. D–F CFLAR expression was positively correlated with CD8 + T cell infiltration in BRCA. G–K Single-cell sequencing of CFLAR in BRCA. L–M Correlation between CFLAR expression and prognosis in patients treated with anti-PD- 1 and anti-PD-L1 therapies. *P < 0.05