Fig. 9

Overexpression of MIR210HG inhibits xenograft tumor growth. A–C Tumor volume size measurements were performed during subcutaneous inoculation of esophageal squamous carcinoma cells in nude mice for 18 days, and nude mice were necropsied after 18 days, and the tumors were exfoliated intact according to subgroups, weighed, and statistically counted; overexpression of MIR210HG significantly reduced the growth rate of the tumors as compared to the control group. D MIR210HG expression was detected by qRT-PCR in tumor specimens from mice in the Vector and OE-MIR210HG groups, respectively. E, F Immunohistochemical Ki67 staining was performed on tumor specimens from mice in the Vector and OE-MIR210HG groups, respectively, and scores were tallied. G, H Protein expression of P53, Bax, C-caspase3, Beclin- 1 and P62 in tumor specimens of mice in the Vector and OE-MIR210HG groups were further detected by Western blot, respectively, and statistically analyzed. *p < 0.05, **p < 0.01, ***p < 0.001