Table 2 A summary of studies investigating quercetin’s effects on muscle injury, fatigue, and damage
From: Polyphenols and post-exercise muscle damage: a comprehensive review of literature
References | Exercise modality | Treatment use | No. of subjects | Population of interest | Treatment duration | Outcomes |
|---|---|---|---|---|---|---|
[97] | Western States Endurance Run | 1000 mg/day | 63 | Humans | 3Â weeks | No significant changes in CRP, Ck, and interleukins |
[98] | Resistance training session | 1000 mg/day | 10 | Humans | Single dose | Enhancing the neuromuscular performance |
[100] | Â | Â | Â | Humans | 8Â weeks | Â |
[99] | 70% V̇O2max cycling for 60 min, followed by 3 h of recovery, then a subsequent single bout of cycling exercise with 75% V̇O2 max to exhaustion | 1000 mg per day | 12 | Humans | 7 days | Increasing high-intensity cycling time to exhaustion, whole-body insulin-stimulated glucose uptake and decreasing exercise-induced oxygen stress and pro-inflammation |
[101] | eccentric exercise | 1000 mg/day | 16 | Humans | 14Â days | Reducing strength loss and decreasing CK and LDH |
[106] | Treadmill 5Â days a week for 6Â weeks | 1000Â mg | 26 | Humans | 8Â weeks | No significant change in lactate concentration, body fat percentage, or VO2 max while increasing time to exhaustion |
[102] | Intensive endurance exercising | 500Â mg/day | 60 | Humans | 8Â weeks | Not improve exercise performance but reducing muscle damage and body fat percent |
[103] | 5Â km running performance, and ran a 10Â km race followed by 100 drop jumps | 140Â mg | 24 women and 33 men | Humans | one hour before competition, followed by three additional doses every eight hours | Decreasing the muscle pain and loss of performance and mechanical impulse |
[104] | An eccentric-induced muscle-damaging protocol | 1g/day | 12 | Humans | 14Â days | Reducing myoglobin, Ck, LDH, and IL-6 and increasing IGF-I and -II |
[122] | 2 separate sessions of 24 eccentric contractions of the elbow flexors | 1000 mg/d | 30 | Humans | 7 days before and 5 days after the second exercise session | Plasma QUE obtained levels of 202 ± 52 ng/ml after seven days and stayed elevated throughout the 5 day recovery |
[105] | Treadmill (28 m/min at 5° slope for 90 min) for seven consecutive days | 100 mg/kg |  | Adult male BALB/C mice | 4 weeks | Decreasing mitochondrial oxidative stress by inhibiting glutathione depletion and aconitase inactivation, ROS over-generation, and lipid peroxidation |