Fig. 8

Consensus clustering of CHB samples. A Consistent matrix plot, where cleaner blank areas between blue modules indicate more successful analysis. B CDF plots of the consistency clusters showing the relative change in consistency indices with CDF values from k = 2 to k = 6, with the k value of the curve with the most stable change being the optimal fractal number. C Area under the curve of the CDF curve from k = 2 to k = 6. D Trace plot of k = 2 to k = 6. E PCA plot of CHB samples. The scatterplot allows visualization of the feature genes that divide CHB into two subtypes, Cluster1 and Cluster2. F Box plots of the difference in expression of feature genes between Cluster1 and Cluster2 of two subtypes of CHB. *p < 0.05, **p < 0.01, ***p < 0.001