Fig. 3
Construction of gene co-expression network. A Cluster tree and heatmap for all samples in GSE83148, the red heatmap corresponds to the clinical characteristics of the samples in that cluster tree. B The optimal soft threshold β = 9 is chosen for the scale-free topological fitting exponent R2 = 0.85 in the left panel to obtain the best average connectivity of the co-expression network in the right panel. C Example of a clustering tree for a merged module. D Heatmap of correlations between modules and clinical features. Red indicates a positive correlation; blue indicates a negative correlation, and the darker the color, the stronger the correlation. The number in parentheses is the p-value of the correlation between the module and the feature. The number above the parentheses indicates the correlation size between the module and the feature. E Scatter plot between dark turquoise module and CHB gene significance, cor = 0.51, p < 0.001. F Scatter plot between royal blue module and CHB gene significance, cor = 0.42, p < 0.01. G Correlation between modules and phenotypes