Fig. 11

Differentiated value of USP21 for the natural courses of CHB. A Differential gene expression of USP21 in HCs and CHB. B Correlation of USP21 gene expression levels with various clinical indicators. Red indicates a positive correlation, and blue indicates a negative correlation. The numbers in the circles indicate the magnitude of the correlation between gene expression levels and clinical indicators. C ROC curve showing the ability of USP21 to distinguish between HCs and CHB. D Differences in USP21 gene expression levels in different natural courses of CHB. E ROC curves showing the efficacy of USP21 in differentiating patients with CHB of different natural courses. F ROC curve showing the efficacy of USP21 in combination with ALT and AST in differentiating CHB of different natural courses. G1 HBeAg-positive chronic HBV infection, G2 HBeAg-positive CHB, G3 HBeAg-negative chronic HBV infection, G4 HBeAg-negative CHB.*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns means p > 0.05