Fig. 6
From: Inducing mononuclear cells of patients with CADASIL to construct a CSVD disease model
Sequencing analysis of CADASIL NOTCH3 R141C vascular organoids and control vascular organoids (M: CADASIL vascular organoids, N: control vascular organoids.) A Volcano plot of differentially expressed genes. The abscissa is the fold change of gene expression in the treatment group and the control group (log2 Fold Change), and the ordinate is the significance level of the gene expression difference between the treatment group and the control group (− log10padj). The blue dotted line represents the threshold line of the differential gene screening standard, the red dots represent up-regulated genes, and the green dots represent down-regulated genes. B Clustered Heatmap of Differentially Expressed Genes. The abscissa is the sample name, and the ordinate is the normalized value of the differential gene FPKM. The redder the color, the higher the expression level, and the greener the color, the lower the expression level. M1, M2 and M3: CADASIL vascular organoids, N1, N2 and N3: control vascular organoids. C Scatter Plot of GO enrichment analysis. D Scatter plot of KEGG enrichment analysis