Fig. 4

Line graph showing trial sequential analysis for all-cause mortality in included randomized controlled trials. The uppermost and lowermost curves represent trial sequential monitoring boundary lines for benefit and harm, respectively. Horizontal lines represent traditional boundaries for statistical significance. The cumulative z-curve represents the trial data. The Z-curve crosses the boundaries of continuous monitoring and routine ineffectiveness in the experiment, indicating that although the sample size did not reach the required amount (n = 4780) of information, glucocorticoid has been shown to reduce the mortality rate of severe community-acquired pneumonia patients. TSA Trial Sequential Analysis