The dual role of diabetes on oral potentially malignant disorders

Table 2 Sensitivity analysis of the associations between diabetes-related traits and oral potentially malignant disorders

Analysis	Exposure	Outcome	Heterogeneity statistics			Horizontal pleiotropy
Analysis	Exposure	Outcome	Cochran's Q	I²	P	Egger intercept	P
Before correction	T1D	AC	47.057	0.384	0.018	− 0.005	0.440
		OLK	49.023	0.408	0.011	− 0.003	0.860
		OLP	84.212	0.656	0.000	0.004	0.745
	T2D	AC	152.565	0.364	0.000	− 0.010	0.093
		OLK	111.670	0.131	0.146	− 0.012	0.250
		OLP	231.559	0.581	0.000	− 0.001	0.886
	HbA1c	AC	119.897	0.491	0.000	− 0.003	0.605
		OLK	84.885	0.281	0.023	− 0.005	0.599
		OLP	104.569	0.417	0.000	− 0.001	0.842
	FG	AC	77.627	0.291	0.024	− 0.003	0.501
		OLK	66.458	0.172	0.138	− 0.002	0.819
		OLP	63.997	0.141	0.190	0.012	0.040
	FI	AC	25.739	0.088	0.587	− 0.002	0.813
		OLK	32.819	0.147	0.242	0.030	0.144
		OLP	42.636	0.343	0.038	− 0.028	0.053
After correction	T1D	AC	21.682	0.107	0.598	− 0.005	0.355
		OLK	19.860	0.309	0.798	0.015	0.186
		OLP	25.652	0.103	0.318	0.010	0.212
	T2D	AC	76.829	0.132	0.774	− 0.007	0.140
		OLK	76.005	0.184	0.854	− 0.003	0.790
		OLP	86.211	0.021	0.534	− 0.008	0.209
	HbA1c	AC	46.329	0.122	0.696	− 0.008	0.066
		OLK	36.167	0.465	0.963	0.001	0.877
		OLP	55.676	0.030	0.412	0.006	0.308
	FG	AC	38.215	0.361	0.923	0.000	0.977
		OLK	45.194	0.128	0.702	− 0.007	0.411
		OLP	51.241	0.034	0.543	0.013	0.023
	FI	AC	17.110	0.520	0.906	0.003	0.765
		OLK	24.148	0.118	0.622	0.022	0.260
		OLP	23.264	0.032	0.504	− 0.018	0.170

T1D type 1 diabetes, T2D type 2 diabetes, FG fasting glucose, FI fasting insulin, HbA1c glycated hemoglobin levels, AC actinic cheilitis, OLP oral lichen planus, OLK oral leukoplakia

ISSN: 2047-783X