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Fig. 2 | European Journal of Medical Research

Fig. 2

From: The dual role of titanium particles in osteolysis: implications for gene therapy in prosthesis loosening

Fig. 2

Ti particle inhibits BMSC differentiation into osteoblasts and downregulates Wnt pathway-related factors. A Alizarin red staining and quantification of BMSCs after osteogenic differentiation for 21 days. B ALP staining of BMSCs after osteogenic differentiation for 7 days. C mRNA expression levels of the osteogenic differentiation markers Runx2, OCN, and OPN after 7 days. D Volcano map of the differentially expressed mRNA between the two groups. Red: up-regulated differential genes; Blue: down-regulated differential genes. E GO enrichment analysis of differentially expressed genes. F mRNA expression levels of Wnt3a and β-catenin. ***P < 0.001, **P < 0.01, and *P < 0.05. Scale bar: 40 µm

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European Journal of Medical Research

ISSN: 2047-783X

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