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Fig. 3 | European Journal of Medical Research

Fig. 3

From: Host-directed therapy for tuberculosis

Fig. 3

Statins and M.tb infection exhibit opposing effects on AMPK, mTORC1, and autophagy. Statins suppress mTORC1 activity while activating AMPK, both of which cause enhanced nuclear translocation of TFEB, resulting in the expression of autophagy-related genes. M.tb produces opposite effects by activating mTORC1 and blocking AMPK, which prevents nuclear translocation of TFEB and inhibits autophagy

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European Journal of Medical Research

ISSN: 2047-783X

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