Fig. 6

SAP30 knockdown inhibits ccRCC progression in vivo. A, B The subcutaneous tumours in 12 nude mice and the isolated tumours are shown. C, D The volumes and weights of the tumours were measured in nude mice. E The tumour volumes were measured at 6, 12, 24 and 48 days after tumour formation. F MT1G mRNA expression was measured by qRT‒PCR in the si-Ctrl and si-SAP30 groups in vivo. G The protein expression levels of SAP30, MT1G and p53 were determined in the si-Ctrl and si-SAP30 groups in vivo. H Hypothetical model of the proposed mechanism by which SAP30 regulates the proliferation and apoptosis of ccRCC cells through the MT1G/p53 axis. *p < 0.05, **p < 0.01, ***p < 0.001