J-shaped association between blood urea nitrogen-to-creatinine ratio and mortality in critically ill patients with acute pancreatitis: a retrospective cohort study using the MIMIC-IV database

Table 4 Subgroup analysis for the association between BUN/Cr ratio and mortality in critically ill patients with AP

	n (%)	< 16.80	≥ 16.80	HR (95%CI)	P	P for interaction
All patients	850 (100.00)	30/425	63/425	1.65 (1.01,2.70)	0.045
28-day mortality
Age						0.348
< 60	425 (50.00)	15/267	12/158	1.03 (0.37,2.91)	0.952
≥ 60	425 (50.00)	15/158	51/267	1.96 (1.00,3.82)	0.049
Gender						0.867
Female	352 (41.41)	10/159	31/193	2.05 (0.84,4.97)	0.113
Male	498 (58.59)	20/266	32/232	2.19 (1.11,4.33)	0.024
CRRT						0.203
No	762 (89.65)	14/373	45/389	2.44 (1.22,4.88)	0.012
Yes	88 (10.35)	16/52	18/36	1.81 (0.71,4.58)	0.214
Beta-blocker						0.192
No	426 (50.12)	22/236	33/190	1.62 (0.81,3.27)	0.176
Yes	424 (49.88)	8/189	30/235	2.12 (0.92,4.90)	0.078
Octreotide						0.938
No	782 (92.00)	25/399	51/383	1.76 (1.02,3.03)	0.042
Yes	68 (8.00)	5/26	12/42	1.51 (0.07,34.31)	0.797
Ventilation						0.397
No	200 (23.53)	7/112	9/88	3.65 (0.58,22.96)	0.168
Yes	650 (76.47)	23/313	54/337	1.72 (0.99,2.97)	0.054
365-day mortality
Age						0.741
< 60	425 (50.00)	26/267	25/158	1.56 (0.81,3.00)	0.187
≥ 60	425 (50.00)	39/158	88/267	1.19 (0.78,1.81)	0.421
Gender						0.927
Female	352 (41.41)	24/159	56/193	1.41 (0.81,2.44)	0.224
Male	498 (58.59)	41/266	57/232	1.85 (1.16,2.93)	0.009
CRRT						0.163
No	762 (89.65)	41/373	89/389	1.63 (1.08,2.44)	0.019
Yes	88 (10.35)	24/52	24/36	1.25 (0.56,2.80)	0.580
Beta-blocker						0.899
No	426 (50.12)	35/236	49/190	1.55 (0.91,2.62)	0.106
Yes	424 (49.88)	30/189	64/235	1.40 (0.88,2.24)	0.155
Octreotide						0.857
No	782 (92.00)	57/399	98/383	1.48 (1.03,2.12)	0.034
Yes	68 (8.00)	8/26	15/42	0.78 (0.10,6.08)	0.814
Ventilation						0.369
No	200 (23.53)	15/112	19/88	1.12 (0.46,2.75)	0.800
Yes	650 (76.47)	50/313	94/337	1.37 (0.94,2.00)	0.102

ISSN: 2047-783X