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Table 3 The relationship between BUN/Cr ratio and mortality in AP patients

From: J-shaped association between blood urea nitrogen-to-creatinine ratio and mortality in critically ill patients with acute pancreatitis: a retrospective cohort study using the MIMIC-IV database

 

Model 1

Model 2

Model 3

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

28-day mortality

BUN/Cr ratio

1.03(1.02, 1.04)

 < 0.001

1.03(1.01, 1.04)

 < 0.001

1.03(1.01, 1.04)

0.003

BUN/Cr ratio quartiles

      

 Q1

Ref

 

Ref

 

Ref

 

 Q2

0.82(0.40, 1.69)

0.597

0.68(0.33, 1.40)

0.290

0.83(0.39, 1.77)

0.631

 Q3

1.25(0.65, 2.42)

0.501

0.96(0.49, 1.88)

0.896

0.88(0.43, 1.81)

0.729

 Q4

2.68(1.51, 4.76)

 < 0.001

1.93(1.06, 3.53)

0.032

2.05(1.03, 4.11)

0.042

P for trend

 

 < 0.001

 

0.003

 

0.018

365-day mortality

BUN/Cr ratio

1.02(1.02, 1.03)

 < 0.0001

1.02(1.01, 1.03)

 < 0.0001

1.02(1.01, 1.03)

0.001

BUN/Cr ratio quartiles

      

 Q1

Ref

 

Ref

 

Ref

 

 Q2

1.34(0.82, 2.19)

0.247

0.98(0.59, 1.63)

0.942

1.13(0.67, 1.90)

0.656

 Q3

1.63(1.01, 2.65)

0.045

1.10(0.67, 1.81)

0.712

0.96(0.57, 1.61)

0.870

 Q4

2.78(1.78, 4.34)

 < 0.001

1.72(1.08, 2.75)

0.023

1.79(1.07, 3.00)

0.026

P for trend

 

 < 0.001

 

0.005

 

0.025

  1. Model 1: no adjustment
  2. Model 2: adjusted for age, gender, and weight
  3. Model 3: adjusted for age, gender, weight, WBC, RBC, hemoglobin, RDW, potassium, anion gap, PTT, SOFA score, APS III score, SAPS II score, AKI, hypertension, malignant tumors, obese, respiratory failure, sepsis, octreotide, vasopressin, and CRRT
  4. BUN blood urea nitrogen, Cr creatinine, WBC white blood cell, RBC red blood cell, RDW red blood cell distribution width, PTT partial thromboplastin time, SOFA sequential organ failure assessment, APS III acute physiology score III, SAPS II simplified acute physiology score II, AKI acute kidney injury, CRRT continuous renal replacement therapy, HR hazard ratio, CI confidence interval
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European Journal of Medical Research

ISSN: 2047-783X

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