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Table 3 Correlations between musculoskeletal symptoms with MSD predictive biological markers in smartphone-addicted university students

From: Smartphone addiction and musculoskeletal associated disorders in university students: biomechanical measures and questionnaire survey analysis

Parameters

Not addicted (36%; n = 90) SAS (18.6–36.1; 1–3 h./day)

Addicted (64%; n = 160) SAS (158.8–175.4; ≥ 3 h./day)

MSD score

MSD score

NDI score

CHDQ score

VAS score

NDI score

CHDQ score

VAS score

TIMP-1 (ng/mL)

 ORcrude (95% CI)*

0.214 (0.178–0.298)a

0.211 (0.150–0.241)b

0.245 (0.210–0.381)c

0.325 (0.250–0.486)c

0.356 (0.310–0.485)c

0.296 (0.225–0.350)c

 ORadjusted (95% CI)#

0.221 (0.198–0.312)a

0.225 (0.154–0.258)b

0.50 (0.254–0.441)c

0.345(0.290–0.510)c

0.360 (0.345–0.524)c

0.312 (0.235–0.380)c

TIMP-2 (ng/mL)

 ORcrude (95% CI)*

0.234 (0.148–0.311)a

0.155 (0.98–0.212)b

0.321 (0.152–0.425)c

0.285 (0.210–0.380)c

0.528 (0.290–0.612)c

0.296 (0.158–0.350)c

 ORadjusted (95% CI)#

0.236(0.160–0.342)a

0.160(0.120–0.275)b

0.332(0.165–0.498)c

0.290 (0.230–0.415) c

0.532(0.320–0.645) c

0.315 (0.165–0.370)c

5-HT (serotonin; ng/ml)

 ORcrude (95% CI)*

0.127 (0.80–0.230)a

0.361 (0.160–0.442)b

0.412 (0.230–0.560)c

0.368 (0.152–0.442)c

0.325 (0.135–0.422)c

0.314 (0.115–0.385)c

 ORadjusted (95% CI)#

0.135 (0.95–0.252)a

0.370 (0.168–0.455)b

0.420 (0.255–0.580)c

0.375 (0.160–0.450)c

0.330 (0.145–0.450)c

0.325 (0.125–0.395)c

TG

 ORcrude (95% CI)*

0.356 (0.280–0.430)a

0.145 (0.80–0.230)b

0.213 (0.180–0.330)c

0.125 (0.70–0.230)c

0.231 (0.120–0.312)c

0.298 (0.175–0.415)c

 ORadjusted (95% CI)#

0.360 (0.290–0.480)a

0.150 (0.90–0.240)b

0.220 (0.210–0.360)c

0.130 (0.80–0.324)c

0.238 (0.160–0.330)c

0.315 (0.185–0.435)c

MDA (μ mole/L)

 ORcrude (95% CI)*

0.125 (0.79–0.200)a

0.378 (0.185–0.430)b

0.218 (0.180–0.350)c

0.235 (0.150–0.345)c

0.275 (0.120–0.377)c

0.432 (0.180–0.530)c

 ORadjusted (95% CI)#

0.140 (0.80–0.230)a

0.385 (0.190–0.490)b

0.228 (0.195–0.370)c

0.240 (0.160–0.390)c

0.290 (0.145–0.412)c

0.450 (0.198–0.590)c

TAC

 ORcrude (95% CI)*

0.324 (0.115–0.490)a

0.148 (0.76–0.280)b

0.185 (0.60–0.215)c

0.256 (0.140–0.350)c

0.219 (0.70–0.310)c

0.318 (0.115–0.430)c

 ORadjusted (95% CI)#

0.345 (0.130–0.530)a

0.155 (0.86–0.330)b

0.195 (0.80–0.230)c

0.265 (0.165–0.413)c

0.230 (0.80–0.350)c

0.328 (0.125–0.470)c

  1. MSD: musculoskeletal disorders; SAS: Smartphone Addiction Scale; NDI: Neck Disability Index; CHDQ: Cornell Hand Discomfort Questionnaire; VAS: Visual Analogue Scale; TIMP-1/TIMP-2: metallopeptidase inhibitor 1/2 (a tissue inhibitor of metalloproteinase); MDA: malondialdehyde; TAC: total antioxidant capacity; TG: triglycerides. 5-HT: 5-hydroxytryptamine (serotonin)
  2. ap < 0.05
  3. bp < 0.01
  4. cp < 0.001
  5. *Significant at the level 0.05 as analyzed by χ2 test
  6. #adjusted for all variables in table as measured by multiple logistic regression