Fig. 2

Development and validation of the DRGPS. a K-means clustering analysis based on DRG-cluster associated DEGs identified two gene clusters; b empirical CDF plots; c delta area plots; d survival analysis; e differential expression of the 10 DRGs in two gene clusters; f correlation between two gene clusters and clinical features; g, h LASSO regression analysis; k qRT-PCR validated the expression of DRGPS risk genes in human HCC cell lines and normal liver cell lines, as well as in HCC and its adjacent tissues; i, j correlation between geneCluster, DRGcluster, and risk score. DRGs, disulfidptosis-related genes; DRGPS, DRG prognostic signature; LASSO, least absolute shrinkage and selection operator; qRT-PCR, quantitative reverse transcription polymerase chain reaction; HCC, hepatocellular carcinoma; the P values were shown as *P < 0.05; **P < 0.01; and ***P < 0.001