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Fig. 1 | European Journal of Medical Research

Fig. 1

From: Effect and mechanism of Dichloroacetate in the treatment of stroke and the resolution strategy for side effect

Fig. 1

Schematic illustration of the DCA regulating energy metabolism after ischemic stroke from anaerobic glycolysis to TCA cycle. DCA reduced the expression of phosphorylated PDH while enhancing the activities of both PDHC and PDH. Furthermore, DCA elevated the levels of Ac-CoA in the IS. PDH is responsible for the irreversible conversion of pyruvate into Ac-CoA, which subsequently enters the TCA cycle to generate energy, thereby facilitating the conversion of pyruvate into ATP. Additionally, levels of lactate in both the brain and blood were reduced, and brain pH returned to normal

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European Journal of Medical Research

ISSN: 2047-783X

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