Variables | POSEIDON Group 3 | P value | POSEIDON Group 4 | P value | ||
---|---|---|---|---|---|---|
PPOS group n = 78 | PPOS + LE group n = 111 | PPOS group n = 154 | PPOS + LE group n = 214 | |||
Transfer outcomes | ||||||
No. of patients | 61 | 97 | 112 | 175 | ||
No. of total FET cycles | 86 | 123 | 156 | 227 | ||
No. of total embryos transferred | 103 | 138 | 192 | 270 | ||
Average of embryos transferred per cycle | 1.2 ± 0.4 | 1.1 ± 0.3 | 0.136 | 1.2 ± 0.4 | 1.2 ± 0.4 | 0.327 |
No. of embryos transferred per cycle | 0.135 | 0.326 | ||||
1 | 69/86 (80.23) | 108/123 (87.80) | 120/156 (76.92) | 184/227 (81.06) | ||
2 | 17/86 (19.77) | 15/123 (12.20) | 36/156 (23.08) | 43/227 (18.94) | ||
Stage of embryo transferred, n (%) | 0.649 | 0.281 | ||||
Cleavage embryo | 65/103 (63.11) | 91/138 (65.94) | 167/192 (86.98) | 225/270 (83.33) | ||
Blastocyst | 38/103 (36.89) | 47/138 (34.06) | 25/192 (13.02) | 45/270 (16.67) | ||
Endometrial thickness (mm) | 9.0 (8.3, 9.7) | 9.1 (8.5, 10.1) | 0.207 | 9.0 (8.2, 9.8) | 9.2 (8.4, 10.0) | 0.128 |
Endometrial preparation, n (%) | 0.526 | 0.193 | ||||
HRT cycles | 67/86 (77.91) | 104/123 (84.55) | 111/156 (71.15) | 176/227 (77.53) | ||
Nature cycles | 6/86 (6.98) | 4/123 (3.25) | 11/156 (7.05) | 20/227 (8.81) | ||
Ovulation induction cycles | 1/86 (1.16) | 1/123 (0.81) | 3/156 (1.92) | 2/227 (0.88) | ||
Down-regulation + HRT cycles | 12/86 (13.95) | 14/123 (11.38) | 31/156 (19.87) | 29/227 (12.78) | ||
Pregnancy outcomes, n (%) | ||||||
Biochemical pregnancy rate | 44/86 (51.16) | 63/123 (51.22) | 0.994 | 35/156 (22.44) | 53/227 (23.35) | 0.835 |
Clinical pregnancy rate | 31/86 (36.05) | 54/123 (43.90) | 0.255 | 29/156 (11.33) | 37/227 (16.30) | 0.560 |
Ongoing pregnancy rate | 24/86 (27.91) | 44/123 (35.77) | 0.232 | 17/156 (10.90) | 25/227 (11.01) | 0.972 |
Miscarriage rate | 7/31 (22.58) | 12/54 (22.22) | 0.970 | 13/29 (44.83) | 15/37 (40.54) | 0.727 |
Live birth rate | 24/86 (27.91) | 42/123 (34.15) | 0.340 | 16/156 (10.26) | 22/227 (9.69) | 0.856 |
Cumulative clinical pregnancy rate | 31/78 (39.74) | 54/111 (48.65) | 0.226 | 29/154 (18.83) | 37/214 (17.29) | 0.704 |
Cumulative live birth rate | 24/78 (30.77) | 42/111 (37.84) | 0.316 | 16/154 (10.39) | 22/214 (10.28) | 0.973 |