Fig. 4

Effects of OM-MSCsNrf2 on the microglial polarization in BV2 cells. A–D CD86 MFI (A, B) and CD206 MFI (C, D) in BV2 cells following the co-culture with OM-MSCs (ctrl) and OM-MSCsNrf2. scale bar: 100 μm. E–H Relative mRNA levels of Cd80 (E), Nos2 (F), Arg1 (G), and Fizz1 (H) in BV2 cells following the co-culture with OM-MSCs (ctrl) and OM-MSCsNrf2. Results of independent triplicates were expressed as mean ± standard deviation and the statistical difference between two groups was marked with asterisks (*p < 0.05, **p < 0.01, and ***p < 0.001). OM-MSCs olfactory mucosa-mesenchymal stem cells, Nrf2 Nuclear Factor Erythroid-Derived 2-Like 2, MFI mean fluorescence intensity, Nos2 nitric oxide synthase 2, Arg1: arginase 1