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Fig. 2 | European Journal of Medical Research

Fig. 2

From: Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model

Fig. 2

Effects of OM-MSCsNrf2 on the survival and angiogenesis and proteins related to PI3K/AKT pathway and apoptosis in PC12 cells. A Effects of OM-MSCs (ctrl) and OM-MSCsNrf2 on the survival of PC12 cells based on CCK-8 assay. B, C Angiogenesis assay in evaluating the angiogenesis of PC12 cells following the co-culture with OM-MSCs (ctrl) and OM-MSCsNrf2. scale bar: 200 μm D, E Ratio of p-PI3K to PI3K and p-AKT to AKT as well as BAX protein level in PC12 cells following the co-culture with OM-MSCs (ctrl) and OM-MSCsNrf2, and those cells treated with minocycline were applied as the positive control. Results of independent triplicates were expressed as mean ± standard deviation and the statistical difference between two groups was marked with asterisks (*p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001). OM-MSCs olfactory mucosa-mesenchymal stem cells, Nrf2 Nuclear Factor Erythroid-Derived 2-Like 2, OD optical density, p-PI3K phosphorylated-PI3K, PI3K Phosphoinositide 3-kinase, p-AKT phosphorylated-AKT, AKT protein kinase B, BAX BCL2 Associated X, GAPDH Glyceraldehyde-3-phosphate dehydrogenase

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European Journal of Medical Research

ISSN: 2047-783X

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