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Table 4 Ventilatory variables and CT severity scores at the onset of ARDS: Survivors versus non-survivors

From: Ventilatory variables and computed tomography features in COVID-19 ARDS and non–COVID-19-related ARDS: a prospective observational cohort study

Variables

COVID-19

Non–COVID-19

 

Survivors (n = 27)

Non-survivors (n = 17)

p value

Survivors (n = 93)

Non-survivors (n = 85)

p value

Ventilator settings

 MP (J/min)

17.8 ± 5.4

20.1 ± 5.9

0.186

18 ± 6.1

20.9 ± 6.5

0.003

 MP/PBW (× 10−3 J/min/kg)

296 ± 89

349 ± 86

0.060

308 ± 101

375 ± 124

 < 0.001

 MP/compliance (J/min/ml/cm H2O)

0.68 ± 0.30

0.89 ± 0.48

0.123

0.69 ± 0.35

0.91 ± 0.53

0.002

 Ventilatory ratio

1.8 ± 0.8

1.9 ± 0.6

0.695

1.8 ± 0.6

2.1 ± 0.7

0.002

 Tidal volume (ml/kg PBW)

8.1 ± 1.4

8.5 ± 2.4

0.511

7.8 ± 1.8

8.4 ± 2.4

0.063

 PEEP (cm H2O)

10.7 ± 2.9

10.2 ± 2.2

0.607

10.8 ± 2.2

10.8 ± 2.1

0.849

 Peak inspiratory pressure (cm H2O)

28 ± 5.1

29.4 ± 5.3

0.404

27.4 ± 5.0

29.5 ± 5.9

0.012

 Mean airway pressure (cm H2O)

15.9 ± 3.4

16.3 ± 2.9

0.743

16 ± 3

16.9 ± 3.1

0.043

 Dynamic driving pressure (cm H2O)

17.3 ± 3.4

19.1 ± 4.0

0.125

16.6 ± 4.5

18.6 ± 5.5

0.008

 Dynamic compliance (ml/cm H2O)

30.1 ± 12.4

27.1 ± 11.4

0.429

30.2 ± 13.6

28.7 ± 15.9

0.491

 Respiratory rate (breaths/min)

20.4 ± 5.8

21.6 ± 4.9

0.454

21.2 ± 4.7

22.9 ± 4.9

0.017

 Minute ventilation (L/min)

9.3 ± 1.9

10.4 ± 2.6

0.139

9.6 ± 2.7

10.6 ± 2.7

0.013

 FiO2 (%)

0.66 ± 0.24

0.68 ± 0.20

0.826

0.55 ± 0.17

0.63 ± 0.19

0.007

Arterial blood gas

 pH

7.39 ± 0.07

7.37 ± 0.11

0.336

7.41 ± 0.07

7.39 ± 0.09

0.361

 PaCO2 (mm Hg)

42.4 ± 13.8

38.9 ± 9.3

0.360

41.9 ± 9.2

42.6 ± 9.0

0.630

 PaO2 (mm Hg)

98.6 ± 49.5

100.4 ± 33.2

0.893

91.7 ± 31.7

86.2 ± 25.2

0.209

 HCO3 (mEq/L)

25.2 ± 5.6

21.6 ± 3.6

0.026

25.9 ± 5.7

25.5 ± 4.9

0.575

 PaO2/FiO2 (mm Hg)

151 (118–220)

135 (97–238)

0.806

168 (123–225)

149 (105–176)

0.008

Ventilation*

 Overinflation

2 (10%)

1 (8.3%)

1.000

11 (15.5%)

1 (2.2%)

0.027

 Normal ventilation

14 (70%)

8 (66.7%)

0.844

17 (23.9%)

3 (6.7%)

0.022

 Collapse

4 (20%)

3 (25%)

1.000

43 (60.6%)

41 (91.1%)

 < 0.001

CT severity score*

 Right upper lobe

2.3 ± 1.3

2.7 ± 1.7

0.500

2.9 ± 1.5

3.9 ± 1.2

 < 0.001

 Right middle lobe

2.7 ± 1.1

2.3 ± 1.1

0.331

2.8 ± 1.4

3.8 ± 0.9

 < 0.001

 Right lower lobe

3.2 ± 1.3

3.3 ± 0.9

0.910

3.8 ± 1.1

4.5 ± 0.7

 < 0.001

 Left upper lobe

2.7 ± 1.2

1.9 ± 0.9

0.075

2.9 ± 1.2

3.8 ± 1.1

 < 0.001

 Left lower lobe

3.1 ± 1.3

3.3 ± 0.9

0.651

3.8 ± 1.2

4.6 ± 0.8

 < 0.001

 Total score

10.8 ± 3.8

10.1 ± 3.6

0.606

16.4 ± 4.5

20.7 ± 3.5

 < 0.001

  1. Data are presented as mean ± standard deviation or median (interquartile range)
  2. ARDS, acute respiratory distress syndrome; COVID-19, coronavirus disease 2019; CT, Computed tomography; FiO2, fraction of inspired oxygen; MP, mechanical power; PaCO2, partial pressure of carbon dioxide in arterial blood; PaO2, partial pressure of oxygen in arterial blood; PBW, predicted body weight; PEEP, positive end-expiratory pressure
  3. *Available for 32 patients with COVID-19 ARDS and 116 patients with non–COVID-19 ARDS
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European Journal of Medical Research

ISSN: 2047-783X

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