Table 2 Ventilatory variables at day 1, 3, and 7 after ARDS onset
Variables | Day 1 | Day 3 | Day 7 | ||||||
|---|---|---|---|---|---|---|---|---|---|
COVID-19 (n = 44) | Non–COVID-19 (n = 178) | p value | COVID-19 (n = 44) | Non–COVID-19 (n = 178) | p value | COVID-19 (n = 44) | Non–COVID-19 (n = 178) | p value | |
Ventilator settings | |||||||||
MP (J/min) | 18.7 ± 5.6 | 19.4 ± 6.4 | 0.504 | 16.8 ± 5.4 | 17.8 ± 6.3 | 0.347 | 14.6 ± 7.1 | 17.4 ± 7.6 | 0.043 |
MP/PBW (× 10−3 J/min/kg) | 317 ± 90 | 340 ± 117 | 0.216 | 287 ± 94 | 311 ± 116 | 0.222 | 253 ± 130 | 304 ± 134 | 0.035 |
MP/compliance (J/min/ml/cm H2O) | 0.76 ± 0.39 | 0.80 ± 0.46 | 0.590 | 0.64 ± 0.41 | 0.75 ± 0.50 | 0.194 | 0.55 ± 0.49 | 0.74 ± 0.52 | 0.029 |
Ventilatory ratio | 1.8 ± 0.7 | 2.0 ± 0.6 | 0.168 | 1.7 ± 0.6 | 2.0 ± 0.7 | 0.018 | 1.7 ± 0.8 | 2.1 ± 0.9 | 0.013 |
Tidal volume (ml/kg PBW) | 8.3 ± 1.8 | 8.1 ± 2.1 | 0.645 | 8.5 ± 2.3 | 7.9 ± 2.2 | 0.136 | 8.5 ± 2.7 | 7.8 ± 2.5 | 0.153 |
PEEP (cm H2O) | 10.5 ± 2.7 | 10.8 ± 2.2 | 0.413 | 10.0 ± 2.3 | 10.4 ± 2.4 | 0.302 | 9.2 ± 2.2 | 10.2 ± 2.5 | 0.018 |
Peak inspiratory pressure (cm H2O) | 28.2 ± 4.9 | 28.5 ± 5.4 | 0.967 | 26.8 ± 4.8 | 27.4 ± 6.4 | 0.616 | 24.2 ± 6.9 | 27.3 ± 6.7 | 0.008 |
Mean airway pressure (cm H2O) | 16.1 ± 3.2 | 16.4 ± 3.1 | 0.503 | 15.3 ± 3.0 | 16.3 ± 3.3 | 0.043 | 15.2 ± 3.7 | 16.2 ± 3.4 | 0.179 |
Dynamic driving pressure (cm H2O) | 17.8 ± 3.5 | 18.0 ± 4.7 | 0.790 | 16.8 ± 3.7 | 17.4 ± 5.3 | 0.413 | 15.1 ± 5.6 | 17.3 ± 5.8 | 0.028 |
Dynamic compliance (ml/cm H2O) | 29 ± 12 | 28.7 ± 12.6 | 0.900 | 31.5 ± 12.5 | 30.6 ± 15 | 0.712 | 38.4 ± 20.1 | 29.5 ± 15.4 | 0.014 |
Respiratory rate (breaths/min) | 20.9 ± 5.5 | 22 ± 4.9 | 0.178 | 19.4 ± 4.7 | 21.6 ± 4.8 | 0.006 | 18.6 ± 6.4 | 21.2 ± 5.5 | 0.017 |
Minute ventilation (L/min) | 9.7 ± 2.3 | 10.1 ± 2.8 | 0.441 | 9.3 ± 2.3 | 9.6 ± 2.6 | 0.432 | 8.7 ± 3.1 | 9.3 ± 3.1 | 0.279 |
FiO2 (%) | 0.67 ± 0.22 | 0.59 ± 0.19 | 0.031 | 0.47 ± 0.13 | 0.53 ± 0.19 | 0.029 | 0.45 ± 0.13 | 0.51 ± 0.18 | 0.049 |
Arterial blood gas | |||||||||
pH | 7.39 ± 0.09 | 7.40 ± 0.08 | 0.291 | 7.41 ± 0.07 | 7.41 ± 0.08 | 0.741 | 7.43 ± 0.06 | 7.41 ± 0.09 | 0.212 |
PaCO2 (mm Hg) | 41.1 ± 12.3 | 42.2 ± 9.1 | 0.483 | 41.1 ± 9.2 | 45.1 ± 9.3 | 0.012 | 42.1 ± 7.5 | 47.5 ± 12.1 | < 0.001 |
PaO2 (mm Hg) | 99.3 ± 43.5 | 89.1 ± 28.8 | 0.146 | 95.7 ± 25.8 | 88.4 ± 38.8 | 0.244 | 98.5 ± 32.9 | 87.1 ± 39.9 | 0.088 |
HCO3 (mEq/L) | 23.8 ± 5.2 | 25.7 ± 5.3 | 0.035 | 25.1 ± 4.6 | 28.1 ± 5.4 | 0.001 | 27.6 ± 4.5 | 29.6 ± 6.6 | 0.029 |
PaO2/FiO2 (mm Hg) | 145 (99–234) | 157 (112–199) | 0.647 | 197 (154–263) | 163 (131–233) | 0.144 | 226 (178–278) | 176 (128–231) | 0.040 |